Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862048 | 0.78 | GABRP (0.35) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL19442746 | 0.77 | CYP1A2 (0.54) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1437835 | 0.76 | CYP1A2 (0.58) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7312929 | 0.76 | CYP1A2 (0.58) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL13726724 | 0.75 | TET2 (0.57) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7036606 | 0.74 | MME (0.39) | CYP1A2NAALAD2 | |
| SCHEMBL8606739 | 0.74 | CYP1A2 (0.56) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL4003923 | 0.74 | GABRP (0.50) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL12622337 | 0.74 | CYP1A2 (0.56) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7646056 | 0.73 | PLA2G2C (0.40) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202717-A2 | NAALADASE INHIBITORS IN ANXIETY AND MEMORY DISORDERS | GUILFORD PHARMACEUTICALS INC. (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001001974-A2 | NAALADASE INHIBITORS IN ANXIETY AND MEMORY DISORDERS | GUILFORD PHARMACEUTICALS INC. (US) | 2001-01-11 | — | — | WO | disclosed |