Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.71 |
| ▸ | MMP3 | P08254 | 7/20 | 0.71 |
| ▸ | MMP7 | P09237 | 6/20 | 0.71 |
| ▸ | MMP13 | P45452 | 4/20 | 0.71 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.69 |
| ▸ | MMP9 | P14780 | 4/20 | 0.67 |
| ▸ | MMP2 | P08253 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7537010 | 1.00 | MMP1 (0.71) | MMP1MMP3MMP7MMP13ADAM17 | |
| SCHEMBL7923816 | 0.99 | MMP1 (0.73) | MMP1MMP3MMP7MMP13ADAM17 | |
| SCHEMBL7923819 | 0.99 | MMP1 (0.73) | MMP1MMP3MMP7MMP13ADAM17 | |
| SCHEMBL31086980 | 0.93 | MMP1 (0.70) | MMP1MMP3MMP7MMP13MMP9 | |
| SCHEMBL7532601 | 0.89 | MMP1 (0.73) | MMP1MMP3MMP7MMP13ADAM17 | |
| SCHEMBL7531694 | 0.89 | MMP1 (0.73) | MMP1MMP3MMP7MMP13ADAM17 | |
| SCHEMBL7532596 | 0.89 | MMP1 (0.73) | MMP1MMP3MMP7MMP13ADAM17 | |
| SCHEMBL7531686 | 0.89 | MMP1 (0.73) | MMP1MMP3MMP7MMP13ADAM17 | |
| SCHEMBL7537969 | 0.88 | MMP1 (0.71) | MMP1MMP3MMP7MMP13ADAM17 | |
| SCHEMBL7535524 | 0.88 | MMP1 (0.75) | MMP1MMP3MMP7MMP13ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-H1992-H1 | INHIBITION OF METALLOPROTEINASES AND TUMOR NECROSIS FACTOR CONVERTASE WHICH DEGRADE PROTEIN COMPONENTS OF EXTRACELLULAR MATRIX | AGOURON PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | claimed |
| WO-1998050348-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-12 | — | — | WO | claimed |
| US-H1992-H1 | INHIBITION OF METALLOPROTEINASES AND TUMOR NECROSIS FACTOR CONVERTASE WHICH DEGRADE PROTEIN COMPONENTS OF EXTRACELLULAR MATRIX | AGOURON PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | disclosed |
| WO-1998050348-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-12 | — | — | WO | disclosed |