Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT3B | Q9UBC3 | 10/20 | 0.78 |
| ▸ | DNMT1 | P26358 | 9/20 | 0.78 |
| ▸ | DOT1L | Q8TEK3 | 6/20 | 0.78 |
| ▸ | EZH2 | Q15910 | 4/20 | 0.78 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.78 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.78 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.78 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.78 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.78 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.78 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.78 |
| ▸ | INMT | O95050 | 1/20 | 0.78 |
| ▸ | NSD2 | O96028 | 1/20 | 0.78 |
| ▸ | PNMT | P11086 | 1/20 | 0.78 |
| ▸ | NNMT | P40261 | 1/20 | 0.78 |
| ▸ | HNMT | P50135 | 1/20 | 0.78 |
| ▸ | WDR5 | P61964 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.78 |
| ▸ | RBBP5 | Q15291 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| S-Adenosylhomocysteine SCHEMBL17316162 | 0.88 | DOT1L (1.00) | DNMT3BDNMT1DOT1LEZH2CARM1 | |
| S-Adenosylhomocysteine SCHEMBL12436336 | 0.88 | DOT1L (1.00) | DNMT3BDNMT1DOT1LEZH2CARM1 | |
| S-Adenosylhomocysteine SCHEMBL18296901 | 0.88 | DOT1L (1.00) | DNMT3BDNMT1DOT1LEZH2CARM1 | |
| S-Adenosylhomocysteine SCHEMBL10871157 | 0.88 | DOT1L (1.00) | DNMT3BDNMT1DOT1LEZH2CARM1 | |
| S-Adenosylhomocysteine SCHEMBL17087726 | 0.88 | DOT1L (1.00) | DNMT3BDNMT1DOT1LEZH2CARM1 | |
| S-Adenosylhomocysteine SCHEMBL16087786 | 0.88 | DOT1L (1.00) | DNMT3BDNMT1DOT1LEZH2CARM1 | |
| S-Adenosylhomocysteine SCHEMBL14411397 | 0.88 | DOT1L (1.00) | DNMT3BDNMT1DOT1LEZH2CARM1 | |
| S-Adenosylhomocysteine SCHEMBL804238 | 0.88 | DOT1L (1.00) | DNMT3BDNMT1DOT1LEZH2CARM1 | |
| S-Adenosylhomocysteine SCHEMBL21160481 | 0.88 | DOT1L (1.00) | DNMT3BDNMT1DOT1LEZH2CARM1 | |
| S-Adenosylhomocysteine SCHEMBL12378912 | 0.88 | DOT1L (1.00) | DNMT3BDNMT1DOT1LEZH2CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3969912-A1 | ENDOMENTRIAL RECEPTIVITY DETERMINATION | Tervisetehnoloogiate Arenduskeskus AS (EE) | 2022-03-23 | — | — | EP | disclosed |
| WO-2020234026-A1 | ENDOMENTRIAL RECEPTIVITY DETERMINATION | TERVISETEHNOLOOGIATE ARENDUSKESKUS AS (EE) | 2020-11-26 | — | — | WO | disclosed |
| WO-2018129040-A9 | MODULATING NUDIX HOMOLOGY DOMAIN (NHD) WITH NICOTINAMIDE MONONUCLEOTIDE ANALOGS AND DERIVATIVES OF SAME | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-10-25 | — | — | WO | disclosed |
| WO-2018129039-A1 | MODULATING NUDIX HOMOLOGY DOMAIN (NHD) WITH NICOTINAMIDE MONONUCLEOTIDE ANALOGS AND DERIVATIVES OF SAME | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-07-12 | — | — | WO | disclosed |
| WO-2018129040-A1 | MODULATING NUDIX HOMOLOGY DOMAIN (NHD) WITH NICOTINAMIDE MONONUCLEOTIDE ANALOGS AND DERIVATIVES OF SAME | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-07-12 | — | — | WO | disclosed |
| EP-1851240-B1 | METHODS AND COMPOSITIONS FOR EXTENDING THE LIFE SPAN AND INCREASING THE STRESS RESISTANCE OF CELLS AND ORGANISMS | HARVARD COLLEGE (US) | 2012-12-12 | — | — | EP | disclosed |
| EP-2431480-A2 | Methods and compositions for increasing the stress resistance of cells and organisms | The President and Fellows of Harvard College (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-1851240-A2 | METHODS AND COMPOSITIONS FOR EXTENDING THE LIFE SPAN AND INCREASING THE STRESS RESISTANCE OF CELLS AND ORGANISMS | The President and Fellows of Harvard College (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006086454-A2 | METHODS AND COMPOSITIONS FOR EXTENDING THE LIFE SPAN AND INCREASING THE STRESS RESISTANCE OF CELLS AND ORGANISMS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2006-08-17 | — | — | WO | disclosed |
| WO-2004016726-A9 | METHODS AND COMPOSITIONS FOR EXTENDING THE LIFE SPAN AND INCREASING THE STRESS RESISTANCE OF CELLS AND ORGANISMS | HARVARD COLLEGE (US) | 2005-08-04 | — | — | WO | disclosed |
| EP-1551964-A2 | METHODS AND COMPOSITIONS FOR EXTENDING THE LIFE SPAN AND INCREASING THE STRESS RESISTANCE OF CELLS AND ORGANISMS | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004016726-A2 | METHODS AND COMPOSITIONS FOR EXTENDING THE LIFE SPAN AND INCREASING THE STRESS RESISTANCE OF CELLS AND ORGANISMS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2004-02-26 | — | — | WO | disclosed |