Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 4/20 | 0.63 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3668564 | 0.82 | TOP2A (0.58) | TOP2AALDH1A1CYP4F2CYP4A11 | |
| SCHEMBL4006211 | 0.79 | TOP2A (0.70) | TOP2AALDH1A1KDM4EPDE5AELANE | |
| SCHEMBL2313196 | 0.79 | TOP2A (0.54) | TOP2AALDH1A1CYP4F2CYP4A11 | |
| SCHEMBL2503500 | 0.79 | TOP2A (0.66) | TOP2ATNFALDH1A1HPGDKDM4E | |
| SCHEMBL12431692 | 0.76 | TOP2A (0.52) | TOP2AALDH1A1CYP4F2CYP4A11 | |
| SCHEMBL2311193 | 0.76 | TOP2A (0.52) | TOP2AALDH1A1HPGDCYP4F2CYP4A11 | |
| SCHEMBL28450779 | 0.75 | TOP2A (0.53) | TOP2AALDH1A1KDM4ECYP4F2CYP4A11 | |
| SCHEMBL3668324 | 0.74 | TOP2A (0.60) | TOP2AALDH1A1KDM4EPDE5AELANE | |
| SCHEMBL10343357 | 0.74 | CNR1 (0.45) | ALDH1A1HPGDKDM4EELANEKMT2A | |
| SCHEMBL7484286 | 0.73 | TOP2A (0.52) | TOP2ATNFALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025101-A1 | NAPHTHO-IMIDAZO 1,2-A]PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999018104-A1 | NAPHTHO-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-04-15 | — | — | WO | disclosed |