Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 4/20 | 0.66 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 1/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11312355 | 0.83 | TOP2A (0.61) | TOP2APDE5AELANECYP3A4CYP2D6 | |
| SCHEMBL11325006 | 0.79 | NLRP3 (0.58) | TOP2APDE5AELANECYP3A4CYP2D6 | |
| SCHEMBL2498217 | 0.79 | TOP2A (0.56) | TOP2APDE5AELANECYP3A4CYP2D6 | |
| SCHEMBL7537296 | 0.79 | TOP2A (0.63) | TOP2APDE5AELANETNFCYP3A4 | |
| SCHEMBL28667127 | 0.77 | TOP2A (0.58) | TOP2APDE5AELANETNFCYP2C19 | |
| SCHEMBL23367961 | 0.76 | KDM4E (0.43) | PDE5AELANECYP3A4CYP2D6CYP2C19 | |
| SCHEMBL22945078 | 0.76 | TOP2A (0.57) | TOP2APDE5AELANETNFCYP2C19 | |
| SCHEMBL27674003 | 0.76 | CYP4F2 (0.65) | TOP2ATNFCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11311241 | 0.76 | TOP2A (0.63) | TOP2APDE5AELANECYP3A4CYP2D6 | |
| SCHEMBL10905069 | 0.75 | SLC2A1 (0.45) | TOP2APOLBRAD52KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637658-B2 | Non-fluorescent quencher compounds and biomolecular assays | APPLIED BIOSYSTEMS, LLC (US) | 2014-01-28 | — | — | US | disclosed |
| US-20130123475-A1 | Non-Fluorescent Quencher Compounds and Biomolecular Assays | Life Technologies Corporation (US) | 2013-05-16 | — | — | US | disclosed |
| US-20120220751-A1 | Non-Fluorescent Quencher Compounds and Biomolecular Assays | Life Technologies Corporation (US) | 2012-08-30 | — | — | US | disclosed |
| US-20110245462-A1 | Non-Fluorescent Quencher Compounds and Biomolecular Assays | Life Technologies Corporation (US) | 2011-10-06 | — | — | US | disclosed |
| US-20090105452-A1 | NON-FLUORESCENT QUENCHER COMPOUNDS AND BIOMOLECULAR ASSAYS | APPLERA CORPORATION (US) | 2009-04-23 | — | — | US | disclosed |
| US-20050164225-A1 | Non-fluorescent quencher compounds and biomolecular assays | APPLIED BIOSYSTEMS, LLC | 2005-07-28 | — | — | US | disclosed |
| US-20040005607-A1 | Non-fluorescent quencher compounds and biomolecular assays | APPLIED BIOSYSTEMS, LLC | 2004-01-08 | — | — | US | disclosed |
| US-20030082547-A1 | Non-fluorescent quencher compounds and biomolecular assays | APPLIED BIOSYSTEMS, LLC | 2003-05-01 | — | — | US | disclosed |
| WO-2003019145-A2 | NON-FLUORESCENT QUENCHER COMPOUNDS AND BIOMOLECULAR ASSAYS | APPLERA CORPORATION (US) | 2003-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050164225-A1 | Non-fluorescent quencher compounds and biomolecular assays | DNTT, PNP, NT5C2 | TOP2A 2356/4885PDE5A 3697/4885ELANE 1262/4885 |
| US-20130123475-A1 | Non-Fluorescent Quencher Compounds and Biomolecular Assays | DNTT, PNP, NT5C2 | TOP2A 2366/4885PDE5A 3865/4885ELANE 1291/4885 |
| US-20030082547-A1 | Non-fluorescent quencher compounds and biomolecular assays | DNTT, PNP, NT5C2 | TOP2A 2132/4885PDE5A 3792/4885ELANE 1393/4885 |
| US-20090105452-A1 | NON-FLUORESCENT QUENCHER COMPOUNDS AND BIOMOLECULAR ASSAYS | DNTT, PNP, NT5C2 | TOP2A 2366/4885PDE5A 3865/4885ELANE 1291/4885 |
| US-20040005607-A1 | Non-fluorescent quencher compounds and biomolecular assays | DNTT, PNP, NT5C2 | TOP2A 2132/4885PDE5A 3792/4885ELANE 1393/4885 |
| US-20110245462-A1 | Non-Fluorescent Quencher Compounds and Biomolecular Assays | DNTT, PNP, NT5C2 | TOP2A 2366/4885PDE5A 3865/4885ELANE 1291/4885 |
| US-20120220751-A1 | Non-Fluorescent Quencher Compounds and Biomolecular Assays | DNTT, PNP, NT5C2 | TOP2A 2366/4885PDE5A 3865/4885ELANE 1291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.