SCHEMBL7537324

SCHEMBL7537324

O=C(NO)c1ccc2[nH]nnc2c1

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 15/20 0.50
CD40 P25942 1/20 0.44
CD40LG P29965 1/20 0.44
HDAC1 Q13547 5/20 0.42
HDAC3 O15379 4/20 0.42
HDAC8 Q9BY41 3/20 0.42
HDAC2 Q92769 2/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
ALOX5 P09917 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27676330 0.87 HDAC6 (0.58) HDAC6HDAC1HDAC3HDAC8HDAC2
SCHEMBL3490877 0.85 CD40 (0.43) CD40CD40LG
SCHEMBL2705734 0.84 ALDH1A1 (0.45) CD40CD40LG
SCHEMBL19029181 0.82 HDAC6 (0.71) HDAC6HDAC1HDAC3HDAC8HDAC2
SCHEMBL446288 0.82 NPC1 (0.55) HDAC6
SCHEMBL7978406 0.81 B3GNT2 (0.44) CD40CD40LG
SCHEMBL22099898 0.81 MAPT (0.53) CD40CD40LG
SCHEMBL7987999 0.81 ALDH1A1 (0.43) CD40CD40LG
SCHEMBL1249005 0.81 TP53 (0.54) CD40CD40LG
SCHEMBL119640 0.81 TDP1 (0.44)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202731-A2 METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2002-05-08 EP disclosed
EP-1144385-A1 BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-10-17 EP disclosed
WO-2001005390-A2 METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-01-25 WO disclosed
WO-2000042022-A1 BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS WARNER-LAMBERT COMPANY (US) 2000-07-20 WO disclosed