Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.47 |
| ▸ | MTOR | P42345 | 11/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | LTK | P29376 | 1/20 | 0.34 |
| ▸ | GRK5 | P34947 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11029448 | 0.93 | MTOR (0.53) | PIK3CAMTORKDM4EDAPK3JAK2 | |
| SCHEMBL11027565 | 0.90 | MTOR (0.53) | PIK3CAMTORKDM4E | |
| SCHEMBL16161710 | 0.87 | MTOR (0.54) | PIK3CAMTOR | |
| SCHEMBL11031097 | 0.86 | MTOR (0.58) | PIK3CAMTOR | |
| SCHEMBL11031207 | 0.85 | MTOR (0.53) | PIK3CAMTORMAPT | |
| SCHEMBL16161620 | 0.82 | MTOR (0.52) | PIK3CAMTOR | |
| SCHEMBL11029456 | 0.82 | MTOR (0.58) | PIK3CAMTORKDM4EDAPK3JAK2 | |
| SCHEMBL11026350 | 0.79 | MTOR (0.58) | PIK3CAMTORDAPK3JAK2PRKD3 | |
| SCHEMBL11030435 | 0.79 | MTOR (0.53) | PIK3CAMTORKDM4EMAPTDAPK3 | |
| SCHEMBL16161680 | 0.79 | MTOR (0.60) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |