Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5119970 | 0.96 | PDE5A (0.44) | PDE5ACLK4CHRM4MEN1KMT2A | |
| SCHEMBL5123186 | 0.89 | PDE5A (0.50) | PDE5ACLK4MEN1KMT2AALDH1A1 | |
| SCHEMBL5119638 | 0.85 | CHRM4 (0.46) | PDE5ACLK4CHRM4MEN1KMT2A | |
| SCHEMBL5121525 | 0.84 | ICAM1 (0.44) | PDE5ACLK4CHRM4MEN1KMT2A | |
| SCHEMBL5122246 | 0.82 | USP1 (0.45) | PDE5ACLK4CHRM4MEN1KMT2A | |
| SCHEMBL5123611 | 0.81 | PDE5A (0.47) | PDE5ACLK4CHRM4MEN1KMT2A | |
| SCHEMBL5124468 | 0.81 | MAPT (0.46) | PDE5ACLK4CHRM4MEN1KMT2A | |
| SCHEMBL5815249 | 0.81 | MAPT (0.58) | PDE5ACLK4MEN1KMT2AALDH1A1 | |
| SCHEMBL27403243 | 0.81 | PDE5A (0.44) | PDE5ACLK4CHRM4MEN1KMT2A | |
| SCHEMBL5130194 | 0.80 | USP1 (0.44) | PDE5AALDH1A1USP1WDR48 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |