⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29010450 | 0.95 | — | — | |
| SCHEMBL10629 | 0.95 | — | — | |
| Fluoride SCHEMBL28089318 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL27824534 | 0.90 | — | — | |
| Dimethyl Sulfone SCHEMBL28083753 | 0.79 | KDM4E (0.46) | — | |
| SCHEMBL19235745 | 0.76 | — | — | |
| SCHEMBL9067987 | 0.76 | NLRP3 (0.35) | — | |
| SCHEMBL4782321 | 0.76 | NLRP3 (0.35) | — | |
| Dimethyl Sulfone SCHEMBL27647353 | 0.74 | — | — | |
| Methanesulfonic Acid Ethyl Ester SCHEMBL5666892 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550269-B1 | PROCESS AND INTERMEDIATES FOR PREPARING LAPATINIB | SCINOPHARM TAIWAN LTD (TW) | 2016-03-23 | — | — | EP | claimed |
| US-20130005971-A1 | Process and Intermediates for Preparing Lapatinib | SCINOPHARM TAIWAN, LTD. (TW) | 2013-01-03 | — | — | US | claimed |
| EP-2550269-B1 | PROCESS AND INTERMEDIATES FOR PREPARING LAPATINIB | SCINOPHARM TAIWAN LTD (TW) | 2016-03-23 | — | — | EP | disclosed |
| US-8710221-B2 | Process and intermediates for preparing lapatinib | SCINOPHARM TAIWAN, LTD. (TW) | 2014-04-29 | — | — | US | disclosed |
| US-20140024829-A1 | PROCESS AND INTERMEDIATES FOR PREPARING LAPATINIB | SCINOPHARM TAIWAN, LTD. (TW) | 2014-01-23 | — | — | US | disclosed |
| US-8563719-B2 | Process and intermediates for preparing lapatinib | SCINOPHARM TAIWAN, LTD. (TW) | 2013-10-22 | — | — | US | disclosed |
| US-20130005971-A1 | Process and Intermediates for Preparing Lapatinib | SCINOPHARM TAIWAN, LTD. (TW) | 2013-01-03 | — | — | US | disclosed |
| US-6462238-B2 | REDUCTION OF THE CORRESPONDING NITRILE CONTAINING COMPOUND | ARRAY BIOPHARMA, INC. | 2002-10-08 | — | — | US | disclosed |
| US-20020013498-A1 | Process for the reduction of cyano-substituted sulfones to aminoalkylene-substituted sulfones | ARRAY BIOPHARMA, INC. | 2002-01-31 | — | — | US | disclosed |