Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 13/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7538764 | 0.87 | MC4R (0.39) | MC4RKDM4ETDP1MEN1ALDH1A1 | |
| SCHEMBL7540521 | 0.80 | MC4R (0.37) | MC4RKCNH2KDM4ETDP1MEN1 | |
| SCHEMBL4824573 | 0.80 | KMT2A (0.43) | MC4RKCNH2KDM4ETDP1MEN1 | |
| SCHEMBL4363678 | 0.79 | KDM4E (0.40) | MC4RKDM4ETDP1MEN1ALDH1A1 | |
| SCHEMBL4363581 | 0.76 | KDM4E (0.51) | MC4RKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL4823163 | 0.75 | KDM4E (0.40) | MC4RKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL7207525 | 0.73 | MC4R (0.43) | MC4RKCNH2KDM4ETDP1MEN1 | |
| SCHEMBL4013095 | 0.72 | KCNH2 (0.57) | MC4RKCNH2 | |
| SCHEMBL4064122 | 0.71 | MC4R (0.56) | MC4RKCNH2KMT2A | |
| SCHEMBL4008428 | 0.69 | MC4R (0.63) | MC4RKCNH2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204645-A2 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001010842-A2 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-02-15 | — | — | WO | disclosed |