SCHEMBL7539128

SCHEMBL7539128

NC(=O)C1c2ccccc2-c2ccc(C(F)(F)CF)cc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 2/20 0.39
HTR2B P41595 7/20 0.36
HTR7 P34969 6/20 0.36
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36
NCOR2 Q9Y618 1/20 0.36
HSD17B1 P14061 1/20 0.35
HSD17B2 P37059 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
MCHR1 Q99705 1/20 0.35
ALDH1A1 P00352 1/20 0.33
GAA P10253 1/20 0.33
PPIA P62937 1/20 0.33
POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7539130 0.77 ATM (0.40) ATMHTR2BHTR7HDAC3HDAC4
SCHEMBL3143561 0.75 ATM (0.61) ATMHTR2BHTR7HDAC3HDAC4
SCHEMBL30250175 0.75 ATM (0.61) ATMHTR2BHTR7HDAC3HDAC4
Trifluoroacetic Acid SCHEMBL8895982 0.75 ATM (0.49) ATMHTR2BHTR7HDAC3HDAC4
SCHEMBL971200 0.70 ATM (0.36) ATMHTR2BHTR7KMT2AALDH1A1
SCHEMBL7539135 0.69 ATM (0.41) ATMHTR2BHTR7HDAC3HDAC4
SCHEMBL30249875 0.66 HDAC3 (0.52) ATMHTR2BHTR7HDAC3HDAC4
SCHEMBL18952633 0.66 HDAC3 (0.52) ATMHTR2BHTR7HDAC3HDAC4
SCHEMBL4859217 0.66 FOLH1 (0.51) POLB
SCHEMBL4597995 0.66 HDAC3 (0.37) ATMHTR2BHTR7HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1181014-A4 HETEROCYCLIC CONTAINING BIPHENYL aP2 INHIBITORS AND METHOD BRISTOL MYERS SQUIBB CO (US) 2002-06-05 EP disclosed
EP-1181014-A1 HETEROCYCLIC CONTAINING BIPHENYL aP2 INHIBITORS AND METHOD BRISTOL-MYERS SQUIBB COMPANY (US) 2002-02-27 EP disclosed
WO-2000059506-A1 HETEROCYCLIC CONTAINING BIPHENYL aP2 INHIBITORS AND METHOD BRISTOL-MYERS SQUIBB CO. (US) 2000-10-12 WO disclosed