Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL755160 | 0.90 | PIK3CD (0.81) | PIK3CDPIK3CGPIK3CBPIK3R1KDM4E | |
| SCHEMBL10296670 | 0.88 | PIK3CD (0.63) | PIK3CDPIK3CGPIK3CBPIK3R1KDM4E | |
| SCHEMBL754908 | 0.85 | PIK3CG (0.57) | PIK3CDPIK3CGKDM4EALDH1A1HPGD | |
| SCHEMBL16596951 | 0.83 | ALDH1A1 (0.63) | PIK3CDPIK3CGALDH1A1TP53 | |
| SCHEMBL788931 | 0.82 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3CBPIK3R1KDM4E | |
| SCHEMBL18896600 | 0.82 | NPC1 (0.47) | PIK3CDPIK3CGPIK3CBPIK3R1KDM4E | |
| SCHEMBL16585042 | 0.81 | PIK3CD (0.86) | PIK3CDPIK3CGPIK3CBPIK3R1KDM4E | |
| SCHEMBL9604076 | 0.79 | PIK3CD (0.76) | PIK3CDPIK3CGPIK3CBPIK3R1KDM4E | |
| SCHEMBL16591381 | 0.79 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CBPIK3R1ALDH1A1 | |
| SCHEMBL18923549 | 0.79 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CBPIK3R1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637533-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2014-01-28 | — | — | US | disclosed |
| US-20120172591-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2012-07-05 | — | — | US | disclosed |
| US-8138195-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138195-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2012-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172591-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PIK3CG | PIK3CD 1/4885PIK3CG 3/4885PIK3CB 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.