Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 17/20 | 0.55 |
| ▸ | IDH1 | O75874 | 2/20 | 0.46 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7543704 | 0.90 | LCK (0.69) | LCK | |
| SCHEMBL7596940 | 0.90 | LCK (0.69) | LCK | |
| SCHEMBL7596936 | 0.90 | LCK (0.69) | LCK | |
| SCHEMBL7867885 | 0.90 | LCK (0.69) | LCK | |
| SCHEMBL7549688 | 0.86 | LCK (0.65) | LCKIDH1 | |
| SCHEMBL7589785 | 0.83 | LCK (0.58) | LCKIDH1 | |
| SCHEMBL7873240 | 0.83 | LCK (0.58) | LCKIDH1 | |
| SCHEMBL7546015 | 0.81 | LCK (0.61) | LCKIDH1 | |
| SCHEMBL7540754 | 0.78 | LCK (0.52) | LCK | |
| SCHEMBL7873023 | 0.77 | LCK (0.49) | LCKIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194152-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-1194152-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6316444-B1 | SRC kinase inhibitor compounds | MERCK & CO., INC. | 2001-11-13 | — | — | US | disclosed |
| WO-2001000214-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |