SCHEMBL7541420

SCHEMBL7541420

C=CC(=O)OC(C)C(=O)CC#N

nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.40
HPGD P15428 1/20 0.32
MCL1 Q07820 2/20 0.31
ALDH1A1 P00352 3/20 0.31
TP53 P04637 2/20 0.31
HIF1A Q16665 2/20 0.31
CYP3A4 P08684 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5845718 0.77 TSHR (0.39) TSHRHPGDMCL1
SCHEMBL11380841 0.76 TSHR (0.44) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL2926510 0.76 MCL1 (0.43) TSHRMCL1
SCHEMBL4906996 0.74 TSHR (0.42) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL6752742 0.74 TSHR (0.42) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL27280826 0.72 HCAR2 (0.45) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL3338067 0.72
SCHEMBL9360192 0.72 MCL1 (0.41) TSHRHPGDMCL1ALDH1A1HSD17B10
SCHEMBL5665734 0.72 TSHR (0.46) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL5665729 0.71 TSHR (0.48) TSHRHPGDALDH1A1TP53HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0726489-B1 Silver halide photographic material FUJI PHOTO FILM CO LTD (JP) 2002-06-05 EP disclosed
EP-0716338-B1 Fine polymer particles having heterogeneous phase structure, silver halide photographic light- sensitive material containing the fine polymer particles and image-forming method FUJI PHOTO FILM CO LTD (JP) 2001-10-04 EP disclosed
US-6027805-A LATEX POLYMER OF FINE PARTICLES HAVING HETEROGENEOUS PHASE STRUCTURE COMPRISING CORE OF CONJUGATED DIENE MONOMER UNITS AND SHELL OF POLYMER HAVING REPEATING UNITS OF ETHYLENICALLY UNSATURATED MONOMER HAVING ACTIVE METHYLENE GROUP; PHOTOGRAPHY FUJI PHOTO FILM CO., LTD. (JP) 2000-02-22 US disclosed
US-5932390-A HYDRAZINE DERIVATIVE AND A POLYMER LATEX HAVING A CORE/SHELL STRUCTURE FUJI PHOTO FILM CO., LTD. (JP) 1999-08-03 US disclosed
US-5744279-A A SUPPORT WITH SILVER HALIDE EMULSION LAYER, EMULSION, COLLOID LAYER, HYDRAZINE GROUP, ANIONIC OR NONIONIC GROUPS FUJI PHOTO FILM CO., LTD. (JP) 1998-04-28 US disclosed
US-5587276-A HYDROQUINONE-FREE DEVELOPING SOLUTION CONTAINING ASCORBIC ACID; HYDROPHILIC COLLOIDAL LAYER CONTAINING A HYDRAZINE DERIVATIVE FUJI PHOTO FILM CO., LTD. (JP) 1996-12-24 US disclosed
EP-0726489-A2 Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1996-08-14 EP disclosed
EP-0716338-A2 Fine polymer particles having heterogeneous phase structure, silver halide photographic light- sensitive material containing the fine polymer particles and image-forming method FUJI PHOTO FILM CO., LTD. (JP) 1996-06-12 EP disclosed