Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.62 |
| ▸ | PDE1A | P54750 | 5/20 | 0.58 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.58 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | PDE6C | P51160 | 1/20 | 0.51 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427820 | 0.89 | PDE5A (0.58) | PDE5APDE6CPDE11A | |
| SCHEMBL7425142 | 0.84 | PDE5A (0.57) | PDE5APDE6CPDE11A | |
| SCHEMBL5827328 | 0.79 | PDE5A (0.89) | PDE5APDE6CPDE11A | |
| SCHEMBL6647593 | 0.78 | PDE5A (0.74) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL975193 | 0.78 | PDE5A (0.90) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL5827692 | 0.78 | PDE5A (0.69) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL2567308 | 0.78 | PDE5A (0.83) | PDE5APDE3BPDE3APDE6CPDE11A | |
| SCHEMBL439392 | 0.78 | PDE5A (0.78) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6309324 | 0.77 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL1190 | 0.77 | PDE5A (0.90) | PDE5APDE1APDE1BPDE1CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999062905-A1 | 8-PHENYLXANTHINE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | ALMIRALL PRODESFARMA, S.A. (ES) | 1999-12-09 | — | — | WO | claimed |