Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846860 | 0.83 | NPC1 (0.48) | NPC1RAB9APOLBCASP3SENP8 | |
| SCHEMBL6846734 | 0.83 | NPC1 (0.48) | NPC1RAB9APOLBCASP3SENP8 | |
| SCHEMBL6846662 | 0.76 | NPC1 (0.53) | NPC1RAB9APOLBCASP3SENP8 | |
| SCHEMBL6845358 | 0.75 | NPC1 (0.47) | NPC1RAB9APOLBCASP3SENP8 | |
| Hydrochloric Acid SCHEMBL6846679 | 0.75 | NPC1 (0.55) | NPC1RAB9APOLBCASP3SENP8 | |
| SCHEMBL6846715 | 0.75 | MMP9 (0.56) | NPC1RAB9APOLBCASP3SENP8 | |
| SCHEMBL6846538 | 0.74 | ATM (0.48) | NPC1RAB9APOLBCASP3SENP8 | |
| SCHEMBL6846907 | 0.74 | BRAF (0.49) | NPC1RAB9APOLBCASP3SENP8 | |
| Hydrochloric Acid SCHEMBL6845436 | 0.74 | ATM (0.47) | NPC1RAB9APOLBCASP3SENP8 | |
| SCHEMBL6841240 | 0.72 | MEN1 (0.47) | NPC1RAB9APOLBLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252146-A1 | AMIDE COMPOUNDS FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2002-10-30 | — | — | EP | claimed |
| WO-2001053274-A1 | AMIDE COMPOUNDS FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2001-07-26 | — | — | WO | claimed |