Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | PGK2 | P07205 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27927523 | 0.69 | — | — | |
| SCHEMBL28483902 | 0.69 | FDPS (0.41) | FDPSBLMTDP1SMPD1PGK1 | |
| SCHEMBL2722876 | 0.69 | — | — | |
| SCHEMBL7461477 | 0.67 | FDPS (0.39) | FDPSBLMTDP1SMPD1PGK1 | |
| Phosphorylisopropane SCHEMBL82996 | 0.67 | — | — | |
| SCHEMBL10429436 | 0.67 | — | — | |
| SCHEMBL4612999 | 0.67 | — | — | |
| SCHEMBL8434615 | 0.67 | — | — | |
| SCHEMBL28901680 | 0.67 | — | — | |
| SCHEMBL5963622 | 0.67 | SMPD1 (0.39) | FDPSBLMTDP1SMPD1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676960-B1 | CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS | AVENTIS PHARM PROD INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-0801644-A4 | POLYARYLCARBAMOYLAZA -AND- CARBAMOYLALKANEDIOIC ACIDS | RHONE POULENC RORER PHARMA (US) | 2001-03-07 | — | — | EP | disclosed |
| EP-0801644-A1 | POLYARYLCARBAMOYLAZA -AND- CARBAMOYLALKANEDIOIC ACIDS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-10-22 | — | — | EP | disclosed |
| US-5596020-A | Amino bi- and tri-carbocyclic alkane bis-aryl squalene synthase inhibitors | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5563128-A | ANTICHOLESTEROL AGENT | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-10-08 | — | — | US | disclosed |
| US-5561143-A | ANTICHOLESTEROL AGENTS, ANTILIPEMIC AGENTS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-10-01 | — | — | US | disclosed |
| US-5556990-A | SQUALENE SYNTHASE INHIBITORS, ANTICHOLESTEROL AGENTS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-09-17 | — | — | US | disclosed |
| US-5534532-A | ANTICHOLESTEROL AGENTS, SQUALENE SYNTHASE INHIBITOR | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-07-09 | — | — | US | disclosed |
| WO-1996018615-A1 | POLYARYLCARBAMOYLAZA -AND- CARBAMOYLALKANEDIOIC ACIDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-06-20 | — | — | WO | disclosed |
| US-5494918-A | ANTICHOLESTEROL AGENTS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-02-27 | — | — | US | disclosed |
| US-5455260-A | Anticholesterol agents; reduction of serum cholesterol without reducing mevalonic metabolite synthesis; side effect | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5451596-A | Cycloalkyl amine bis-aryl squalene synthase inhibitors | RHONE POULENC RORER PHARMACEUTICALS INC. (US) | 1995-09-19 | — | — | US | disclosed |
| US-5441946-A | Anticholesterol agents | RHONE-POULENC-RORER PHARMACEUTICALS, INC. (US) | 1995-08-15 | — | — | US | disclosed |
| US-5395846-A | Amino Bi- and tri-carbocyclic aklane bis-aryl squalene synthase inhibitors | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-03-07 | — | — | US | disclosed |
| US-5385912-A | Hypocholesterolemic or hypolipidemic agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-01-31 | — | — | US | disclosed |
| WO-1995000146-A1 | AMINO BI- AND TRI-CARBOCYCLIC ALKANE BIS-ARYL SQUALENE SYNTHASE INHIBITORS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-01-05 | — | — | WO | disclosed |
| WO-1994027601-A1 | ALIPHATIC AMINO BIS-ARYL SQUALENE SYNTHASE INHIBITORS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-12-08 | — | — | WO | disclosed |
| WO-1994014435-A1 | CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-07-07 | — | — | WO | disclosed |
| US-5317015-A | Azacyclic bisphosphonates as anticholesterolemic agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-05-31 | — | — | US | disclosed |
| WO-1992015579-A1 | MULTICYCLIC TERTIARY AMINE POLYAROMATIC SQUALENE SYNTHETASE INHIBITORS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-09-17 | — | — | WO | disclosed |