Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846672 | 0.87 | MEN1 (0.41) | MEN1KMT2AKEAP1NFE2L2CASP3 | |
| SCHEMBL7490334 | 0.73 | TRPV1 (0.52) | MAPTPOLBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7548979 | 0.71 | TRPV1 (0.41) | MAPTHTTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6841468 | 0.69 | LMNA (0.46) | MEN1KMT2AKEAP1NFE2L2CASP3 | |
| SCHEMBL7541530 | 0.68 | LMNA (0.44) | MEN1KMT2AKEAP1NFE2L2CASP3 | |
| SCHEMBL6846845 | 0.68 | HPGD (0.44) | MEN1KMT2AKEAP1NFE2L2CASP3 | |
| SCHEMBL6846899 | 0.66 | HPGD (0.44) | MEN1KMT2AKEAP1NFE2L2CASP3 | |
| SCHEMBL6841239 | 0.66 | MAP3K20 (0.43) | MEN1KMT2AKEAP1NFE2L2CASP3 | |
| SCHEMBL7495398 | 0.65 | MAPK1 (0.53) | RAB9ANPC1THRBALDH1A1 | |
| SCHEMBL6846667 | 0.65 | HPGD (0.43) | MEN1KMT2AKEAP1NFE2L2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252146-A1 | AMIDE COMPOUNDS FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001053274-A1 | AMIDE COMPOUNDS FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2001-07-26 | — | — | WO | disclosed |