Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.83 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.63 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8074280 | 1.00 | DRD2 (0.83) | DRD2GRIN2BMTNR1AMTNR1BDRD3 | |
| SCHEMBL8074250 | 1.00 | DRD2 (0.83) | DRD2GRIN2BMTNR1AMTNR1BDRD3 | |
| Hydrochloric Acid SCHEMBL8604442 | 0.99 | DRD2 (0.81) | DRD2GRIN2BMTNR1AMTNR1BDRD3 | |
| Hydrochloric Acid SCHEMBL7932989 | 0.99 | DRD2 (0.81) | DRD2GRIN2BMTNR1AMTNR1BDRD3 | |
| SCHEMBL5146494 | 0.94 | DRD2 (0.74) | DRD2GRIN2BMTNR1AMTNR1BDRD3 | |
| SCHEMBL3320662 | 0.91 | DRD2 (1.00) | DRD2GRIN2BMTNR1AMTNR1BDRD3 | |
| SCHEMBL339286 | 0.91 | DRD2 (1.00) | DRD2GRIN2BMTNR1AMTNR1BDRD3 | |
| SCHEMBL29354627 | 0.91 | DRD2 (1.00) | DRD2GRIN2BMTNR1AMTNR1BDRD3 | |
| SCHEMBL15474018 | 0.91 | DRD2 (1.00) | DRD2GRIN2BMTNR1AMTNR1BDRD3 | |
| SCHEMBL338733 | 0.91 | DRD2 (1.00) | DRD2GRIN2BMTNR1AMTNR1BDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883599-B1 | AMINOTETRALIN DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | ASTRAZENECA AB (SE) | 2002-06-05 | — | — | EP | disclosed |
| EP-0883599-A1 | AMINOTETRALIN DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | ZENECA LIMITED (GB) | 1998-12-16 | — | — | EP | disclosed |
| US-5807897-A | MUSCULAR DISORDERS | ZENECA LIMITED (GB) | 1998-09-15 | — | — | US | disclosed |
| WO-1997031887-A1 | AMINOTETRALIN DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | ZENECA LIMITED (GB) | 1997-09-04 | — | — | WO | disclosed |