Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 19/20 | 0.88 |
| ▸ | IMPDH1 | P20839 | 3/20 | 0.68 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1474411 | 0.94 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1473366 | 0.92 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL7549462 | 0.91 | IMPDH2 (0.85) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6496613 | 0.89 | IMPDH2 (0.72) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL3995894 | 0.89 | IMPDH2 (0.82) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1475387 | 0.86 | IMPDH2 (0.82) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1474596 | 0.86 | IMPDH2 (0.88) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL4253104 | 0.85 | IMPDH2 (0.80) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL4258273 | 0.85 | IMPDH2 (0.80) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6500687 | 0.85 | IMPDH2 (0.76) | IMPDH2IMPDH1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020052513-A1 | Oxamide IMPDH inhibitors | HOFFMANN-LA ROCHE INC. | 2002-05-02 | — | — | US | disclosed |
| EP-1127883-A2 | Oxamides as IMPDH inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052513-A1 | Oxamide IMPDH inhibitors | IMPDH1, IMPDH2, IMPA1 | IMPDH2 2/4885IMPDH1 1/4885AAK1 2882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.