Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 7/20 | 0.45 |
| ▸ | DRD3 | P35462 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22837453 | 0.80 | HTR2A (0.47) | HTR2ADRD2DRD3HTR1ACHRM2 | |
| SCHEMBL7542801 | 0.80 | HTR2A (0.47) | HTR2ADRD2DRD3HTR1ACHRM2 | |
| SCHEMBL5034348 | 0.76 | HTR2A (0.48) | HTR2ADRD2DRD3HTR1ACHRM2 | |
| SCHEMBL20478471 | 0.76 | CHRM2 (0.45) | HTR2ADRD2DRD3HTR1ACHRM2 | |
| SCHEMBL3163101 | 0.74 | HTR2A (0.43) | HTR2ADRD2DRD3HTR1ADRD4 | |
| SCHEMBL10321230 | 0.73 | DRD2 (0.46) | HTR2ADRD2DRD3HTR1A | |
| SCHEMBL20478601 | 0.73 | CA12 (0.46) | HTR2AHTR1A | |
| SCHEMBL10321232 | 0.73 | DRD2 (0.46) | HTR2ADRD2DRD3HTR1A | |
| SCHEMBL22837450 | 0.71 | CETP (0.46) | HTR2ADRD2DRD3HTR1A | |
| SCHEMBL9870482 | 0.70 | ABCB1 (0.64) | HTR2ADRD2DRD3HTR1ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0940386-B1 | Benzocyclobutan compounds, their process for preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-05-22 | — | — | EP | disclosed |
| US-6107345-A | ANTIDEPRESSANT; PSYCHOLOGICAL DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-08-22 | — | — | US | disclosed |
| EP-0940386-A1 | Benzocyclobutan compounds, their process for preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-09-08 | — | — | EP | disclosed |