Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 12/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GPR4 | P46093 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764465 | 0.89 | CCR5 (0.46) | CCR5KCNH2CNR2GPR4 | |
| Hydrochloric Acid SCHEMBL5765862 | 0.88 | CCR5 (0.46) | CCR5KCNH2CNR2GPR4 | |
| SCHEMBL5764335 | 0.81 | CCR5 (0.48) | CCR5KCNH2GPR4 | |
| SCHEMBL5764647 | 0.80 | CCR5 (0.50) | CCR5KCNH2 | |
| SCHEMBL7493987 | 0.79 | MAPT (0.49) | CCR5KCNH2GPR4 | |
| SCHEMBL7224003 | 0.79 | HRH1 (0.48) | CCR5KCNH2HRH1HRH3 | |
| SCHEMBL5763292 | 0.79 | PLAT (0.42) | CCR5PLAT | |
| SCHEMBL5761438 | 0.79 | PLAT (0.46) | CCR5PLAT | |
| SCHEMBL5762566 | 0.78 | CCR5 (0.50) | CCR5HRH1PLAT | |
| Hydrochloric Acid SCHEMBL7660201 | 0.78 | PLAT (0.42) | CCR5PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171122-A4 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1171122-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6248755-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| WO-2000059502-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |