Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA3 | P07451 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7544208 | 1.00 | DRD2 (0.53) | DRD2DRD3ACHEOPRK1HSD17B10 | |
| SCHEMBL7544213 | 1.00 | DRD2 (0.53) | DRD2DRD3ACHEOPRK1HSD17B10 | |
| Hydrochloric Acid SCHEMBL4784856 | 0.87 | KDM4E (0.47) | HSD17B10MAPTALDH1A1NFKB1HIF1A | |
| Hydrochloric Acid SCHEMBL4784862 | 0.87 | KDM4E (0.47) | HSD17B10MAPTALDH1A1NFKB1HIF1A | |
| SCHEMBL9192945 | 0.81 | TTR (0.52) | DRD2DRD3ACHECA12CA1 | |
| SCHEMBL9196820 | 0.81 | TTR (0.52) | DRD2DRD3ACHECA12CA1 | |
| SCHEMBL9193730 | 0.81 | TTR (0.52) | DRD2DRD3ACHECA12CA1 | |
| Hydrochloric Acid SCHEMBL9131273 | 0.80 | TTR (0.51) | DRD2DRD3ACHECA12CA1 | |
| Hydrochloric Acid SCHEMBL9134646 | 0.80 | TTR (0.51) | DRD2DRD3ACHECA12CA1 | |
| Hydrochloric Acid SCHEMBL9134385 | 0.80 | TTR (0.51) | DRD2DRD3ACHECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894787-B1 | 3,4-DISUBSTITUTED PHENYLETHANOLAMINOTETRALINCARBOXYLATE DERIVATIVES | KISSEI PHARMACEUTICAL (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-6136852-A | 3,4-disubstituted phenylethanolaminotetralincarboxylic acid derivatives | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0894787-A1 | 3,4-DISUBSTITUTED PHENYLETHANOLAMINOTETRALINCARBOXYLATE DERIVATIVES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1999-02-03 | — | — | EP | disclosed |