Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20937700 | 0.98 | CYP2D6 (0.48) | CYP2D6TBXAS1CNR2CYP3A4CYP2C19 | |
| SCHEMBL11898919 | 0.98 | CYP2D6 (0.48) | CYP2D6TBXAS1CNR2CYP3A4CYP2C19 | |
| SCHEMBL28080853 | 0.98 | CYP2D6 (0.48) | CYP2D6TBXAS1CNR2CYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL11899838 | 0.96 | CYP2D6 (0.47) | CYP2D6TBXAS1CNR2CYP3A4CYP2C19 | |
| SCHEMBL11900019 | 0.94 | CYP2D6 (0.42) | CYP2D6TBXAS1CNR2CYP3A4CYP2C19 | |
| Bromide SCHEMBL28799569 | 0.92 | CYP2D6 (0.41) | CYP2D6TBXAS1CNR2CYP3A4CYP2C19 | |
| Fluoride SCHEMBL30330792 | 0.92 | CYP2D6 (0.41) | CYP2D6TBXAS1CNR2CYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL11898482 | 0.92 | CYP2D6 (0.45) | CYP2D6TBXAS1CNR2CYP3A4CYP2C19 | |
| SCHEMBL27966926 | 0.86 | TAAR1 (0.39) | CYP2D6TBXAS1CNR2CYP3A4CYP2C19 | |
| SCHEMBL7072643 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826667-B1 | 2 Aryl 5 (trifluoromethyl) 2 pyrroline compounds and process for the manufacture of insecticidal, 2 aryl 1 (alkoxymethyl) 4 halo 5 (trifluoromethyl) pyrroles | BASF AG (DE) | 2002-10-30 | — | — | EP | claimed |
| CN-1046503-C | 2-aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trifluoromethyl) pyrroles | AMERICAN CYANAMID CO (US) | 1999-11-17 | — | — | CN | claimed |
| EP-0826667-A1 | 2 Aryl 5 (trifluoromethyl) 2 pyrroline compounds and process for the manufacture of insecticidal, 2 aryl 1 (alkoxymethyl) 4 halo 5 (trifluoromethyl) pyrroles | AMERICAN CYANAMID COMPANY (US) | 1998-03-04 | — | — | EP | claimed |
| CN-1117963-A | 2-aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trifluoromethyl) pyrroles | AMERICAN CYANAMID CO (US) | 1996-03-06 | — | — | CN | claimed |
| US-5194630-A | Halogenation and etherification of 2-aryl-1-methyl-2-pyrroline | AMERICAN CYANAMID COMPANY (US) | 1993-03-16 | — | — | US | claimed |
| CN-1063281-A | 2-aryl-5- (trifluoromethyl) -2-pyrroline compounds and process for preparing insecticide, 2-aryl-1- (alkoxymethyl) -4-halo-5- (trifluoromethyl) pyrrole | AMERICAN CYANAMID CO (US) | 1992-08-05 | — | — | CN | claimed |
| EP-0492171-A1 | 2-Aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trofluoromethyl) pyrroles | AMERICAN CYANAMID COMPANY (US) | 1992-07-01 | — | — | EP | claimed |
| US-7560257-B2 | Diagnostic methods for age related macular degeneration | THE CLEVELAND CLINIC FOUNDATION (US) | 2009-07-14 | — | — | US | disclosed |
| US-7560257-B2 | Diagnostic methods for age related macular degeneration | THE CLEVELAND CLINIC FOUNDATION (US) | 2009-07-14 | — | — | US | disclosed |
| US-20080160505-A1 | DIAGNOSTIC METHODS FOR AGE RELATED MACULAR DEGENERATION | THE CLEVELAND CLINIC FOUNDATION | 2008-07-03 | — | — | US | disclosed |
| US-20080160505-A1 | DIAGNOSTIC METHODS FOR AGE RELATED MACULAR DEGENERATION | THE CLEVELAND CLINIC FOUNDATION | 2008-07-03 | — | — | US | disclosed |
| US-7341839-B2 | Diagnostic methods for age related macular degeneration | THE CLEVELAND CLINIC FOUNDATION (US) | 2008-03-11 | — | — | US | disclosed |
| US-20070072241-A1 | diagnosing age-related macular degeneration comprising determining the level of anti-2-( omega -carboxyethyl) pyrrole (CEP) antibodies in a bodily fluid obtained from the test subject | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-03-29 | — | — | US | disclosed |
| CN-1117963-A | 2-aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trifluoromethyl) pyrroles | AMERICAN CYANAMID CO (US) | 1996-03-06 | — | — | CN | disclosed |
| CN-1116487-A | 2-aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trifluoromethyl)pyrroles | AMERICAN CYANAMID CO (US) | 1996-02-14 | — | — | CN | disclosed |
| CN-1030765-C | Process for the preparation of pyrroline intermediates useful in the preparation of arylpyrrole insecticides | AMERICAN CYANAMID CO (US) | 1996-01-24 | — | — | CN | disclosed |
| US-5362746-A | Process for the manufacture of insecticidal 2-aryl-1-(alkoxymethyl)-4-halo-5-(trifluoromethyl)pyrroles | AMERICAN CYANAMID COMPANY (US) | 1994-11-08 | — | — | US | disclosed |
| US-5194630-A | Halogenation and etherification of 2-aryl-1-methyl-2-pyrroline | AMERICAN CYANAMID COMPANY (US) | 1993-03-16 | — | — | US | disclosed |
| CN-1063281-A | 2-aryl-5- (trifluoromethyl) -2-pyrroline compounds and process for preparing insecticide, 2-aryl-1- (alkoxymethyl) -4-halo-5- (trifluoromethyl) pyrrole | AMERICAN CYANAMID CO (US) | 1992-08-05 | — | — | CN | disclosed |
| EP-0492171-A1 | 2-Aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trofluoromethyl) pyrroles | AMERICAN CYANAMID COMPANY (US) | 1992-07-01 | — | — | EP | disclosed |