Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.49 |
| ▸ | FEN1 | P39748 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5060798 | 0.83 | CES2 (0.74) | TSHRCES2CES1ERCC5FEN1 | |
| SCHEMBL29787113 | 0.83 | TSHR (0.65) | TSHRCES2CES1ERCC5FEN1 | |
| SCHEMBL112377 | 0.83 | TSHR (0.65) | TSHRCES2CES1ERCC5FEN1 | |
| SCHEMBL4878766 | 0.81 | TSHR (0.63) | TSHRCES2CES1ERCC5FEN1 | |
| Hydrochloric Acid SCHEMBL4097230 | 0.81 | TSHR (0.63) | TSHRCES2CES1ERCC5FEN1 | |
| SCHEMBL7547483 | 0.81 | TSHR (0.69) | TSHRCES2CES1ERCC5FEN1 | |
| SCHEMBL29904615 | 0.80 | TSHR (1.00) | TSHRCES2CES1ERCC5FEN1 | |
| SCHEMBL97298 | 0.80 | TSHR (1.00) | TSHRCES2CES1ERCC5FEN1 | |
| SCHEMBL3131575 | 0.79 | TSHR (0.61) | TSHRCES2CES1ERCC5FEN1 | |
| Hydrochloric Acid SCHEMBL4097228 | 0.79 | TSHR (0.61) | TSHRCES2CES1ERCC5FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800520-B1 | PROCESS FOR THE PREPARATION OF LAMOTRIGINE | WELLCOME FOUND (GB) | 2002-06-19 | — | — | EP | claimed |
| US-5912345-A | CHEMICAL CONDENSATION WITH CYCLIZATION AFTER TREATMENT WITH ULTRAVIOLET OR VISIBLE RADIATION | GLAXO WELLCOME INC. (US) | 1999-06-15 | — | — | US | claimed |
| EP-0800520-B1 | PROCESS FOR THE PREPARATION OF LAMOTRIGINE | WELLCOME FOUND (GB) | 2002-06-19 | — | — | EP | disclosed |
| US-5912345-A | CHEMICAL CONDENSATION WITH CYCLIZATION AFTER TREATMENT WITH ULTRAVIOLET OR VISIBLE RADIATION | GLAXO WELLCOME INC. (US) | 1999-06-15 | — | — | US | disclosed |
| EP-0800520-A1 | PROCESS FOR THE PREPARATION OF LAMOTRIGINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020934-A1 | PROCESS FOR THE PREPARATION OF LAMOTRIGINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-07-11 | — | — | WO | disclosed |