Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 2/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | CPA1 | P15085 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26291258 | 0.91 | DPP4 (0.44) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL8819205 | 0.91 | DPP4 (0.44) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL7199464 | 0.84 | DPP4 (0.43) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL7199462 | 0.84 | DPP4 (0.43) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| Val-Gly SCHEMBL2782029 | 0.83 | ALDH1A1 (0.57) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| Val-Gly SCHEMBL2782025 | 0.83 | ALDH1A1 (0.57) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| Val-Gly SCHEMBL21436907 | 0.81 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| Val-Gly SCHEMBL21436906 | 0.81 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL30869183 | 0.77 | METAP1 (0.38) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL31517310 | 0.76 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTPTGS2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206273-A2 | PEPTIDES THAT BLOCK VIRAL INFECTIVITY AND METHODS OF USE THEREOF | TRIPEP AB (SE) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001010456-A2 | PEPTIDES THAT BLOCK VIRAL INFECTIVITY AND METHODS OF USE THEREOF | TRIPEP AB (SE) | 2001-02-15 | — | — | WO | disclosed |