Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.51 |
| ▸ | RAB9A | P51151 | 11/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 6/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10424691 | 0.86 | NPC1 (0.55) | NPC1RAB9APOLBLMNAKDM4E | |
| SCHEMBL17545934 | 0.83 | NPC1 (0.47) | NPC1RAB9APOLBLMNAKDM4E | |
| SCHEMBL352438 | 0.83 | NPC1 (0.49) | NPC1RAB9APOLBLMNAKDM4E | |
| SCHEMBL29814388 | 0.83 | NPC1 (0.49) | NPC1RAB9APOLBLMNAKDM4E | |
| SCHEMBL110113 | 0.83 | NPC1 (0.71) | NPC1RAB9APOLBLMNAKDM4E | |
| SCHEMBL29489567 | 0.83 | NPC1 (0.71) | NPC1RAB9APOLBLMNAKDM4E | |
| SCHEMBL2602710 | 0.82 | NPC1 (0.53) | NPC1RAB9APOLBLMNAKDM4E | |
| SCHEMBL9264904 | 0.82 | NPC1 (0.55) | NPC1RAB9APOLBLMNAKDM4E | |
| SCHEMBL8017347 | 0.82 | NPC1 (0.58) | NPC1RAB9APOLBLMNAKDM4E | |
| SCHEMBL29491989 | 0.82 | NPC1 (0.58) | NPC1RAB9APOLBLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576527-B1 | 5-THIO-SUBSTITUTED BENZOTRIAZOLE UV-ABSORBERS AND STABILIZED COMPOSITIONS | CIBA SC HOLDING AG (CH) | 2002-05-22 | — | — | EP | disclosed |
| US-5942626-A | REACTING A 5-HALO-SUBSTITUTED BENZOTRIAZOLE WITH A MERCAPTO COMPOUND IN THE PRESENCE OF A GROUP 1A METAL OR GROUP 2A COMPOUND FORMING 5-THIO-SUBSTITUTED 2H-BENZOTRIAZOLES HAVING ENHANCED ABSORBANCE AT LONGER WAVELENGTHS | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1999-08-24 | — | — | US | disclosed |
| US-5516914-A | Compositions stabilized with 5-thio-substituted benzotriazole UV-absorbers | CIBA-GEIGY CORPORATION (US) | 1996-05-14 | — | — | US | disclosed |
| US-5278314-A | N-Phenol-substituted benzotriazoles | CIBA-GEIGY CORPORATION (US) | 1994-01-11 | — | — | US | disclosed |