Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 8/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756244 | 0.84 | NR3C2 (0.53) | NR3C2PIK3CDPIK3R1MTORSCN9A | |
| SCHEMBL756352 | 0.81 | NR3C2 (0.50) | NR3C2PIK3CDPIK3R1MTORGAA | |
| SCHEMBL755818 | 0.80 | SCN9A (0.56) | NR3C1SCN9A | |
| SCHEMBL753806 | 0.78 | NR3C2 (0.79) | NR3C2KEAP1PGR | |
| SCHEMBL754931 | 0.75 | NR3C2 (0.86) | NR3C2NR3C1PGRAR | |
| SCHEMBL15712669 | 0.75 | HPGD (0.44) | PIK3CDPIK3R1MTORGAAHPGD | |
| SCHEMBL6362106 | 0.74 | HPGD (0.56) | GAAHPGD | |
| SCHEMBL23768829 | 0.73 | KDM4E (0.44) | HPGD | |
| SCHEMBL23768991 | 0.73 | NPC1 (0.49) | GAAHPGD | |
| SCHEMBL31490337 | 0.73 | NPC1 (0.49) | GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984345-B9 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | disclosed |
| EP-1984345-B1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-08-31 | — | — | EP | disclosed |