Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756352 | 0.90 | NR3C2 (0.50) | NR3C2MEN1KMT2APIK3CDGAA | |
| SCHEMBL754538 | 0.84 | NR3C2 (0.53) | NR3C2PIK3CDSCN9AGAAHPGD | |
| SCHEMBL755857 | 0.80 | NR3C2 (0.80) | NR3C2MEN1KMT2AGFERSCN9A | |
| SCHEMBL756990 | 0.78 | NR3C2 (0.56) | NR3C2MEN1KMT2APIK3CDGAA | |
| SCHEMBL753196 | 0.72 | NR3C2 (0.77) | NR3C2MEN1KMT2AADRA2CADRA1A | |
| SCHEMBL755904 | 0.72 | NR3C2 (0.77) | NR3C2ADRA2CADRA1AADRA1B | |
| SCHEMBL756833 | 0.71 | NR3C2 (0.77) | NR3C2MEN1KMT2ASCN9AADRA2C | |
| SCHEMBL756315 | 0.71 | NR3C2 (0.75) | NR3C2ADRA2CADRA1AADRA1B | |
| SCHEMBL753564 | 0.71 | NR3C2 (0.75) | NR3C2GAAHPGDMAPK1ADRA2C | |
| SCHEMBL743757 | 0.71 | NR3C2 (0.75) | NR3C2MEN1KMT2AGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984345-B9 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | claimed |
| EP-1984345-B1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-08-31 | — | — | EP | claimed |