Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7545951 | 1.00 | CHRNB2 (0.48) | CHRNB2CHRNA4TUBB4ATUBBTUBA3C | |
| SCHEMBL6255110 | 0.77 | CHRNB2 (0.56) | CHRNB2CHRNA4HTR2AGRIK1GRIK2 | |
| SCHEMBL6253226 | 0.77 | CHRNB2 (0.56) | CHRNB2CHRNA4HTR2AGRIK1GRIK2 | |
| SCHEMBL6253103 | 0.77 | CHRNB2 (0.56) | CHRNB2CHRNA4HTR2AGRIK1GRIK2 | |
| SCHEMBL6253231 | 0.77 | CHRNB2 (0.56) | CHRNB2CHRNA4HTR2AGRIK1GRIK2 | |
| SCHEMBL6255116 | 0.77 | CHRNB2 (0.56) | CHRNB2CHRNA4HTR2AGRIK1GRIK2 | |
| SCHEMBL6253108 | 0.77 | CHRNB2 (0.56) | CHRNB2CHRNA4HTR2AGRIK1GRIK2 | |
| SCHEMBL7548336 | 0.76 | CHRNB2 (0.43) | CHRNB2CHRNA4ALDH1A1TDP1CYP3A4 | |
| SCHEMBL7548328 | 0.76 | CHRNB2 (0.43) | CHRNB2CHRNA4ALDH1A1TDP1CYP3A4 | |
| SCHEMBL7549120 | 0.75 | CHRNB2 (0.42) | CHRNB2CHRNA4ALDH1A1GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214288-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Targacept Inc. (US) | 2002-06-19 | — | — | EP | claimed |
| US-6337351-B1 | AROMATIC OLEFIN AMINES | TARGACEPT, INC. | 2002-01-08 | — | — | US | claimed |
| WO-2001017943-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. (US) | 2001-03-15 | — | — | WO | claimed |
| EP-1214288-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Targacept Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| EP-1214288-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Targacept Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| US-6337351-B1 | AROMATIC OLEFIN AMINES | TARGACEPT, INC. | 2002-01-08 | — | — | US | disclosed |
| US-6337351-B1 | AROMATIC OLEFIN AMINES | TARGACEPT, INC. | 2002-01-08 | — | — | US | disclosed |
| WO-2001017943-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. (US) | 2001-03-15 | — | — | WO | disclosed |
| WO-2001017943-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. (US) | 2001-03-15 | — | — | WO | disclosed |