Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.52 |
| ▸ | EDNRA | P25101 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4631374 | 1.00 | EDNRB (0.52) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL4631580 | 0.79 | EDNRB (0.47) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL4630655 | 0.76 | EDNRB (0.54) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL4631437 | 0.74 | EDNRA (0.57) | EDNRBEDNRATAAR1 | |
| SCHEMBL11484963 | 0.68 | LMNA (0.36) | EDNRAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL30844611 | 0.67 | HPGD (0.45) | MEN1KMT2AALDH1A1LMNACYP1A2 | |
| SCHEMBL2772816 | 0.67 | LMNA (0.38) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4702032 | 0.66 | KMT2A (0.49) | MEN1KMT2AALDH1A1CNR2CYP1A2 | |
| SCHEMBL143961 | 0.66 | CYP1A2 (0.68) | MEN1KMT2AALDH1A1CYP1A2CYP2A6 | |
| SCHEMBL11288839 | 0.66 | CYP1A2 (0.68) | MEN1KMT2AALDH1A1CYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980369-A1 | SULFONAMIDES FOR TREATMENT OF ENDOTHELIN-MEDIATED DISORDERS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998049162-A1 | SULFONAMIDES FOR TREATMENT OF ENDOTHELIN-MEDIATED DISORDERS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |