Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 8/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7543009 | 0.81 | MAPK11 (0.50) | MAPK11MAPK14HTR2ACDK9GSK3B | |
| SCHEMBL7567570 | 0.79 | MAPK11 (0.55) | MAPK11MAPK14HTR2ASIGMAR1CCNT1 | |
| SCHEMBL2063653 | 0.75 | TMEM97 (0.47) | HTR2AHTR2CHTR2BTMEM97SIGMAR1 | |
| SCHEMBL26773930 | 0.75 | HTR2A (0.65) | HTR2AHTR2CHTR2BCDC7CCNT1 | |
| SCHEMBL26773932 | 0.75 | HTR2A (0.65) | HTR2AHTR2CHTR2BCDC7CCNT1 | |
| SCHEMBL26773936 | 0.75 | HTR2A (0.65) | HTR2AHTR2CHTR2BCDC7CCNT1 | |
| SCHEMBL12422661 | 0.72 | TMEM97 (0.53) | HTR2AHTR2CHTR2BTMEM97SIGMAR1 | |
| SCHEMBL21714635 | 0.71 | HTR2A (0.51) | HTR2AHTR2CHTR2BTMEM97SIGMAR1 | |
| SCHEMBL5850081 | 0.70 | MAPK11 (0.81) | MAPK11MAPK14CDK2GSK3BCDK1 | |
| SCHEMBL13064304 | 0.70 | TMEM97 (0.59) | HTR2AHTR2CHTR2BTMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204662-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS Allelix Corp. (CA) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001012629-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS ALLELIX CORP. (US) | 2001-02-22 | — | — | WO | disclosed |