Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28499086 | 0.95 | SIGMAR1 (0.51) | APPHRH3SIGMAR1MCHR1DDB1 | |
| SCHEMBL220097 | 0.89 | SIGMAR1 (0.62) | SIGMAR1DDB1CRBNL3MBTL1CYP2C9 | |
| SCHEMBL10841960 | 0.88 | APP (0.62) | APPHRH3SIGMAR1MCHR1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL10843610 | 0.86 | APP (0.61) | APPHRH3SIGMAR1MCHR1L3MBTL1 | |
| SCHEMBL5704266 | 0.83 | SIGMAR1 (0.54) | HRH3SIGMAR1MCHR1DDB1CRBN | |
| SCHEMBL28497387 | 0.82 | MCHR1 (0.57) | APPHRH3SIGMAR1MCHR1DDB1 | |
| SCHEMBL8024414 | 0.80 | SIGMAR1 (0.58) | SIGMAR1DDB1CRBNCYP2C9CYP2C19 | |
| SCHEMBL7265760 | 0.79 | DDB1 (0.48) | SIGMAR1DDB1CRBNL3MBTL1CYP2C9 | |
| SCHEMBL13083472 | 0.77 | MCHR1 (0.56) | APPHRH3SIGMAR1MCHR1L3MBTL1 | |
| SCHEMBL930649 | 0.77 | MCHR1 (0.56) | APPHRH3SIGMAR1MCHR1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815091-B1 | POLYAZACYCLOALKANE COMPOUNDS | NYCOMED IMAGING AS (NO) | 2002-06-12 | — | — | EP | disclosed |
| EP-0815091-A1 | POLYAZACYCLOALKANE COMPOUNDS | NYCOMED IMAGING AS (NO) | 1998-01-07 | — | — | EP | disclosed |
| US-5705637-A | Polyazacycloalkane compounds | NYCOMED IMAGING AS (NO) | 1998-01-06 | — | — | US | disclosed |
| US-5677446-A | Polyazacycloalkane compounds | NYCOMED IMAGING AS (NO) | 1997-10-14 | — | — | US | disclosed |
| US-5631368-A | Polyazacycloalkane compounds | NYCOMED IMAGING AS (NO) | 1997-05-20 | — | — | US | disclosed |
| WO-1996028433-A1 | POLYAZACYCLOALKANE COMPOUNDS | NYCOMED IMAGING A.S (NO) | 1996-09-19 | — | — | WO | disclosed |