Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Biricodar. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC1 known ✓ | P33527 | 1/20 | 1.00 |
| ▸ | FKBP1A | P62942 | 20/20 | 1.00 |
| ▸ | FKBP4 | Q02790 | 3/20 | 1.00 |
| ▸ | FKBP5 | Q13451 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biricodar SCHEMBL29405867 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4FKBP5ABCC1 | |
| Biricodar SCHEMBL154547 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4FKBP5ABCC1 | |
| Biricodar SCHEMBL13038499 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL29393244 | 0.98 | FKBP1A (1.00) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL7129468 | 0.98 | FKBP1A (1.00) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL14401254 | 0.98 | FKBP1A (1.00) | FKBP1AFKBP4FKBP5ABCC1 | |
| Biricodar SCHEMBL355913 | 0.92 | FKBP1A (0.85) | FKBP1AFKBP4FKBP5ABCC1 | |
| Biricodar SCHEMBL29860052 | 0.92 | FKBP1A (0.85) | FKBP1AFKBP4FKBP5ABCC1 | |
| Biricodar SCHEMBL1648827 | 0.92 | FKBP1A (0.84) | FKBP1AFKBP4FKBP5ABCC1 | |
| SCHEMBL3673581 | 0.88 | FKBP1A (0.78) | FKBP1AFKBP4FKBP5ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5620971-A | Biologically active acylated amino acid derivatives | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1997-04-15 | — | — | US | claimed |
| EP-0662958-B1 | 1-(2-OXO-ACETYL)-PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES AS MULTI-DRUG-RESISTENT CANCER CELL SENSITIZERS | VERTEX PHARMA (US) | 2002-12-11 | — | — | EP | disclosed |