Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.48 |
| ▸ | CDK9 | P50750 | 4/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5763738 | 0.99 | MKNK1 (0.47) | MKNK1MKNK2CDK9IGF1RCCNT1 | |
| SCHEMBL5764334 | 0.85 | MKNK1 (0.47) | MKNK1MKNK2DRD2DRD4MEN1 | |
| Hydrochloric Acid SCHEMBL5765492 | 0.84 | GABRA1 (0.46) | MKNK1MKNK2DRD2DRD4MEN1 | |
| SCHEMBL5760970 | 0.77 | MKNK1 (0.60) | MKNK1MKNK2CDK9CCNT1PLAT | |
| SCHEMBL5762028 | 0.77 | MKNK1 (0.45) | MKNK1MKNK2CDK9IGF1RDRD2 | |
| Trifluoroacetic Acid SCHEMBL7547215 | 0.76 | CDK2 (0.45) | MKNK1MKNK2CDK9MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5763412 | 0.76 | CDK2 (0.45) | MKNK1MKNK2CDK9MEN1KMT2A | |
| SCHEMBL5763716 | 0.75 | MKNK1 (0.48) | MKNK1MKNK2CDK9CCNT1DRD2 | |
| SCHEMBL5765218 | 0.75 | MKNK1 (0.70) | MKNK1MKNK2DRD2DRD4PLAT | |
| SCHEMBL5762663 | 0.74 | MEN1 (0.63) | MKNK1MKNK2CDK9IGF1RPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192133-A1 | N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076972-A1 | N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-12-21 | — | — | WO | disclosed |