Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.67 |
| ▸ | DRD3 | P35462 | 4/20 | 0.67 |
| ▸ | DRD4 | P21917 | 3/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30440801 | 1.00 | DRD2 (0.67) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| SCHEMBL7540827 | 1.00 | DRD2 (0.67) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| Hydrochloric Acid SCHEMBL30510685 | 0.98 | DRD2 (0.65) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| Hydrochloric Acid SCHEMBL7540241 | 0.98 | DRD2 (0.65) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| Hydrochloric Acid SCHEMBL7540838 | 0.98 | DRD2 (0.65) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| Hydrochloric Acid SCHEMBL7540431 | 0.98 | DRD2 (0.65) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| SCHEMBL7540251 | 0.89 | DRD2 (0.56) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| SCHEMBL7543096 | 0.89 | DRD2 (0.58) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| Hydrochloric Acid SCHEMBL7541528 | 0.88 | DRD2 (0.55) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| Hydrochloric Acid SCHEMBL7540811 | 0.88 | DRD2 (0.57) | DRD2DRD3DRD4ADRA1AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883599-B1 | AMINOTETRALIN DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | ASTRAZENECA AB (SE) | 2002-06-05 | — | — | EP | claimed |