Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.54 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.43 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | LTK | P29376 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7555739 | 0.92 | CHEK1 (0.67) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL8584419 | 0.84 | NTRK1 (0.63) | CHEK1NTRK1RETKDRNTRK3 | |
| SCHEMBL8584423 | 0.84 | NTRK1 (0.63) | CHEK1NTRK1RETKDRNTRK3 | |
| SCHEMBL8467705 | 0.83 | CHEK1 (0.73) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL8467707 | 0.83 | CHEK1 (0.73) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7551557 | 0.81 | CHEK1 (0.60) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7551548 | 0.81 | CHEK1 (0.60) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL8528517 | 0.80 | TLK2 (0.42) | CHEK1NTRK1RETKDRNTRK3 | |
| SCHEMBL7556312 | 0.80 | CHEK1 (0.58) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7556317 | 0.80 | CHEK1 (0.58) | CHEK1CHEK2CDK1SRCCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715628-B1 | SUBSTITUTED AZAINDOLYLIDENE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA ITALIA SPA (IT) | 2002-10-02 | — | — | EP | claimed |
| EP-0715628-A1 | SUBSTITUTED AZAINDOLYLIDENE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-06-12 | — | — | EP | claimed |
| WO-1996000226-A1 | SUBSTITUTED AZAINDOLYLIDENE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA S.P.A. (IT) | 1996-01-04 | — | — | WO | claimed |
| EP-0715628-B1 | SUBSTITUTED AZAINDOLYLIDENE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA ITALIA SPA (IT) | 2002-10-02 | — | — | EP | disclosed |
| US-5663346-A | ENZYME INHIBITORS | PHARMACIA S.P.A. (IT) | 1997-09-02 | — | — | US | disclosed |
| EP-0715628-A1 | SUBSTITUTED AZAINDOLYLIDENE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-06-12 | — | — | EP | disclosed |
| WO-1996000226-A1 | SUBSTITUTED AZAINDOLYLIDENE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA S.P.A. (IT) | 1996-01-04 | — | — | WO | disclosed |