Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 5/20 | 0.35 |
| ▸ | CA9 | Q16790 | 5/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3745415 | 0.77 | MAPK8 (0.41) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| SCHEMBL1983844 | 0.77 | ALDH1A1 (0.43) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| SCHEMBL27103142 | 0.77 | TYRO3 (0.50) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| SCHEMBL21455110 | 0.73 | MAPK8 (0.39) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| SCHEMBL22652124 | 0.73 | MAPK8 (0.44) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| SCHEMBL29828263 | 0.73 | MAPK8 (0.36) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| SCHEMBL22652309 | 0.73 | MAPK8 (0.39) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| SCHEMBL660796 | 0.73 | MEN1 (0.40) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| SCHEMBL31474510 | 0.72 | MAPK8 (0.39) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| SCHEMBL2234905 | 0.72 | NPC1 (0.42) | PDE3BPDE3AALDH1A1LMNACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254137-A1 | PYRIDO 2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001055147-A1 | PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-08-02 | — | — | WO | disclosed |