Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31432475 | 0.94 | HDAC1 (0.43) | GAAHDAC1L3MBTL1TSHRGRM2 | |
| SCHEMBL8651923 | 0.88 | CA1 (0.42) | GAAHDAC1L3MBTL1TSHRGRM2 | |
| SCHEMBL31432277 | 0.87 | HDAC1 (0.46) | GAAHDAC1L3MBTL1TSHRGRM2 | |
| SCHEMBL8649584 | 0.86 | CA1 (0.40) | GAAALDH1A1GFERHDAC1L3MBTL1 | |
| SCHEMBL8649580 | 0.86 | CA1 (0.40) | GAAALDH1A1GFERHDAC1L3MBTL1 | |
| SCHEMBL8652875 | 0.86 | CA1 (0.43) | GAAHDAC1L3MBTL1TSHRGRM2 | |
| SCHEMBL8649137 | 0.84 | MTNR1A (0.42) | GAAHDAC1L3MBTL1TSHRGRM2 | |
| SCHEMBL31431973 | 0.84 | GRM2 (0.44) | GAAHDAC1L3MBTL1TSHRGRM2 | |
| SCHEMBL7407052 | 0.83 | HDAC1 (0.48) | GAAHDAC1L3MBTL1TSHRGRM2 | |
| SCHEMBL31292271 | 0.82 | MTNR1A (0.43) | GAAHDAC1L3MBTL1TSHRGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5719152-A | Tricyclic quinoxalinedione derivatives | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |
| EP-0627434-A1 | Tricyclic quinoxalinedione derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-12-07 | — | — | EP | disclosed |