Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Dalfampridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 6/20 | 0.43 |
| ▸ | ACACA | Q13085 | 5/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dalfampridine SCHEMBL7540843 | 0.90 | ATM (0.58) | KMT2AATMMEN1MAPK1ACACB | |
| Dalfampridine SCHEMBL7539205 | 0.90 | KMT2A (0.59) | KMT2AATMMEN1MAPK1NPY5R | |
| SCHEMBL28057007 | 0.83 | KMT2A (0.82) | KMT2AATMMEN1MAPK1ACACB | |
| SCHEMBL388984 | 0.83 | KMT2A (0.82) | KMT2AATMMEN1MAPK1ACACB | |
| SCHEMBL388983 | 0.83 | KMT2A (0.82) | KMT2AATMMEN1MAPK1ACACB | |
| SCHEMBL16606805 | 0.83 | KMT2A (0.68) | KMT2AATMMEN1MAPK1ACACB | |
| SCHEMBL30309096 | 0.83 | KMT2A (0.68) | KMT2AATMMEN1MAPK1ACACB | |
| SCHEMBL18011186 | 0.83 | KMT2A (0.68) | KMT2AATMMEN1MAPK1ACACB | |
| SCHEMBL25964575 | 0.83 | KMT2A (0.68) | KMT2AATMMEN1MAPK1ACACB | |
| Aminobenzoic Acid SCHEMBL7274588 | 0.82 | KMT2A (0.70) | KMT2AATMMEN1MAPK1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873253-A | Phenylalanine derivative and proteinase inhibitor | Okamoto, Shosuke (JP) | 1989-10-10 | — | — | US | disclosed |
| EP-0284632-A1 | Phenylalanine derivative and proteinase inhibitor | Okamoto, Shosuke (JP) | 1988-10-05 | — | — | EP | disclosed |