Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.70 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7081660 | 0.92 | REN (0.77) | RENLTA4HMCHR1EPHX2HTT | |
| SCHEMBL7081656 | 0.92 | REN (0.77) | RENLTA4HMCHR1EPHX2HTT | |
| SCHEMBL6041928 | 0.85 | REN (0.56) | RENLTA4HMCHR1EPHX2HTT | |
| SCHEMBL7560382 | 0.84 | REN (0.70) | RENLTA4HMCHR1KMT2ANPC1 | |
| SCHEMBL7131244 | 0.82 | REN (1.00) | REN | |
| SCHEMBL6041247 | 0.82 | REN (1.00) | REN | |
| SCHEMBL6041249 | 0.82 | REN (1.00) | REN | |
| SCHEMBL6041330 | 0.81 | REN (0.75) | RENLTA4HMCHR1EPHX2 | |
| SCHEMBL6043618 | 0.81 | REN (0.75) | RENLTA4HMCHR1EPHX2 | |
| SCHEMBL6043614 | 0.81 | REN (0.75) | RENLTA4HMCHR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |