Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.43 |
| ▸ | HTR2C | P28335 | 5/20 | 0.43 |
| ▸ | HTR7 | P34969 | 5/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | TACR2 | P21452 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7031040 | 0.74 | HTR2A (0.48) | HTR2AHTR2CHTR7HTR6GRM2 | |
| SCHEMBL7030100 | 0.71 | CYP2C9 (0.50) | HTR2AHTR2CHTR7HTR6GRM2 | |
| SCHEMBL7027100 | 0.70 | SSTR5 (0.47) | HTR2AHTR2CHTR7HTR6GRM2 | |
| SCHEMBL14495108 | 0.69 | HTR2A (0.67) | HTR2AHTR2CHTR7HTR6GRM2 | |
| SCHEMBL7026680 | 0.69 | HTR2A (0.55) | HTR2AHTR2CHTR7HTR6KCNH2 | |
| SCHEMBL7029343 | 0.69 | HTR2A (0.59) | HTR2AHTR2CHTR7HTR6GRM2 | |
| SCHEMBL7025728 | 0.69 | MEN1 (0.49) | HTR2AHTR2CHTR7HTR6MEN1 | |
| SCHEMBL7028399 | 0.68 | PRCP (0.50) | HTR2AHTR2CHTR7HTR6HRH1 | |
| SCHEMBL7032885 | 0.68 | HTR2A (0.46) | HTR2AHTR2CHTR7HTR6KCNH2 | |
| SCHEMBL7029794 | 0.68 | SIGMAR1 (0.57) | HTR2AHTR2CHTR7HTR6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246803-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT 2A? RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051469-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2001-07-19 | — | — | WO | disclosed |