Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490664 | 0.80 | SIGMAR1 (0.57) | SIGMAR1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL17704774 | 0.77 | NPC1 (0.73) | SIGMAR1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL11483702 | 0.71 | NPC1 (0.52) | SIGMAR1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9204931 | 0.69 | NPC1 (0.56) | SIGMAR1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL725564 | 0.69 | SIGMAR1 (1.00) | SIGMAR1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL11435304 | 0.69 | MEN1 (0.41) | SIGMAR1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL1161143 | 0.69 | MEN1 (0.50) | SIGMAR1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7670580 | 0.69 | NPC1 (0.50) | SIGMAR1NPC1RAB9AMEN1KMT2A | |
| Bromide SCHEMBL4392392 | 0.68 | SIGMAR1 (1.00) | SIGMAR1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL27501569 | 0.68 | SIGMAR1 (0.56) | SIGMAR1NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4587047-A | 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines | E. R. SQUIBB & SONS, INC. (US) | 1986-05-06 | — | — | US | claimed |
| CN-1159303-C | Preparation of intermediate for monocyclic beta-lactams derivatives | ER | 2004-07-28 | — | — | CN | disclosed |
| EP-0578761-B1 | ENZYMATIC PROCESS FOR THE PRODUCTION OF CEFONICID | SMITHKLINE BEECHAM CORP (US) | 2002-06-26 | — | — | EP | disclosed |
| CN-1067053-C | A process for preparing the intermediate of the derivatives of monocycle beta-lactam antibiotics | SQUIBB & SONS INC (US) | 2001-06-13 | — | — | CN | disclosed |
| US-6071712-A | Enzymatic process for the production of cephalosporins | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-06 | — | — | US | disclosed |
| CN-1251836-A | Preparation of intermediate for monocyclic beta-lactams derivatives | SQUIBB & SONS INC (US) | 2000-05-03 | — | — | CN | disclosed |
| US-5705645-A | Hereroaryl derivatives of monocyclic beta-lactam antibiotics | E. R. SQUIBB & SONS, INC. (US) | 1998-01-06 | — | — | US | disclosed |
| CN-1031825-C | Process for the preparation of heteroaroyl derivatives of monocyclic beta-lactam antibiotics | SQUIBB & SONS INC (US) | 1996-05-22 | — | — | CN | disclosed |
| CN-1113228-A | A process for preparing the intermediate of the derivatives of monocycle beta-lactam antibiotics | SQUIBB & SONS INC (US) | 1995-12-13 | — | — | CN | disclosed |
| EP-0578761-A4 | ENZYMATIC PROCESS FOR THE PRODUCTION OF CEFONICID. | SMITHKLINE BEECHAM CORP (US) | 1995-08-09 | — | — | EP | disclosed |
| US-4551276-A | 2-Oxoazetidin-1-yloxymethyl sulfonic acid and analogs | E. R. SQUIBB & SONS, INC. (US) | 1985-11-05 | — | — | US | disclosed |
| US-4548747-A | 3-Acylamino-1-sulfonylaminocarbonylmethoxy-2-azetidinones | E. R. SQUIBB & SONS, INC. (US) | 1985-10-22 | — | — | US | disclosed |
| US-4548751-A | (2-Oxo-1-azetidinyloxy)-2-propenoic acid | E. R. SQUIBB & SONS, INC. (US) | 1985-10-22 | — | — | US | disclosed |
| US-4534896-A | 3-Acylamino-2-oxoazetidine-1-(β-oxopropionic acid) | E. R. SQUIBB & SONS, INC. (US) | 1985-08-13 | — | — | US | disclosed |
| EP-0138407-A1 | Azetidinones | E.R. Squibb & Sons, Inc. (US) | 1985-04-24 | — | — | EP | disclosed |
| EP-0135814-A1 | 1-(1H-tetrazol-5-ylalkoxy)-2-azetidinones | E.R. Squibb & Sons, Inc. (US) | 1985-04-03 | — | — | EP | disclosed |
| EP-0132356-A1 | Process for preparing 2-azetidinones | E.R. Squibb & Sons, Inc. (US) | 1985-01-30 | — | — | EP | disclosed |
| EP-0127177-A2 | [[(3-Acylamino-2-oxo-1-azetidinyl)oxy]methyl]phosphinic acids | E.R. Squibb & Sons, Inc. (US) | 1984-12-05 | — | — | EP | disclosed |
| EP-0124123-A1 | 3-Acylamino-1-sulfonylaminocarbonylmethoxy-2-azetidinones | E.R. Squibb & Sons, Inc. (US) | 1984-11-07 | — | — | EP | disclosed |
| EP-0085291-A1 | 2-Oxo-1-(aminocarbonylaminosulfonylaminocarbonyl)azetidines | E.R. Squibb & Sons, Inc. (US) | 1983-08-10 | — | — | EP | disclosed |