Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.65 |
| ▸ | FLT1 | P17948 | 5/20 | 0.65 |
| ▸ | FLT4 | P35916 | 5/20 | 0.65 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | QPCT | Q16769 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7551621 | 0.95 | KDR (0.64) | KDRFLT1FLT4SMYD2OPRK1 | |
| SCHEMBL7553945 | 0.94 | KDR (0.66) | KDRFLT1FLT4SMYD2OPRK1 | |
| SCHEMBL7549576 | 0.89 | KDR (0.51) | KDRFLT1FLT4SMYD2KMT2A | |
| SCHEMBL7513681 | 0.88 | KDR (0.65) | KDRFLT1FLT4OPRK1NR4A2 | |
| SCHEMBL7551275 | 0.87 | KDR (0.47) | KDRFLT1FLT4SMYD2KMT2A | |
| SCHEMBL7555418 | 0.87 | KDR (0.47) | KDRFLT1FLT4SMYD2KMT2A | |
| SCHEMBL7987672 | 0.86 | KDR (0.47) | KDRFLT1FLT4SMYD2 | |
| SCHEMBL7549814 | 0.86 | FLT1 (0.47) | KDRFLT1FLT4SMYD2KMT2A | |
| SCHEMBL7514027 | 0.86 | KDR (0.65) | KDRFLT1FLT4OPRK1NR4A2 | |
| SCHEMBL7554304 | 0.84 | KDR (0.54) | KDRFLT1FLT4SMYD2NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |