Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.47 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 4/20 | 0.39 |
| ▸ | QPCT | Q16769 | 4/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987156 | 0.95 | KDR (0.46) | KDRFLT1FLT4SMYD2MEN1 | |
| SCHEMBL7551283 | 0.93 | KDR (0.49) | KDRFLT1FLT4SMYD2GSK3B | |
| SCHEMBL7987672 | 0.93 | KDR (0.47) | KDRFLT1FLT4SMYD2HRH3 | |
| SCHEMBL7549576 | 0.93 | KDR (0.51) | KDRFLT1FLT4SMYD2GSK3B | |
| SCHEMBL7551275 | 0.92 | KDR (0.47) | KDRFLT1FLT4SMYD2GSK3B | |
| SCHEMBL7549814 | 0.88 | FLT1 (0.47) | KDRFLT1FLT4SMYD2HRH3 | |
| SCHEMBL7993627 | 0.88 | KDR (0.45) | KDRFLT1FLT4SMYD2HRH3 | |
| SCHEMBL7991040 | 0.88 | FLT1 (0.47) | KDRFLT1FLT4NR3C1 | |
| SCHEMBL7554912 | 0.87 | KDR (0.50) | KDRFLT1FLT4SMYD2HRH3 | |
| SCHEMBL7549476 | 0.87 | KDR (0.65) | KDRFLT1FLT4SMYD2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |