Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 0.71 |
| ▸ | SYK | P43405 | 5/20 | 0.71 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.68 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.59 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.59 |
| ▸ | FCER2 | P06734 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.54 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549757 | 1.00 | NTRK1 (0.71) | NTRK1SYKCHEK1NTRK3NTRK2 | |
| SCHEMBL8467707 | 0.83 | CHEK1 (0.73) | NTRK1SYKCHEK1NTRK3NTRK2 | |
| SCHEMBL5182671 | 0.83 | NTRK1 (1.00) | NTRK1SYKCHEK1NTRK3NTRK2 | |
| SCHEMBL5182676 | 0.83 | NTRK1 (1.00) | NTRK1SYKCHEK1NTRK3NTRK2 | |
| SCHEMBL8467705 | 0.83 | CHEK1 (0.73) | NTRK1SYKCHEK1NTRK3NTRK2 | |
| SCHEMBL7553386 | 0.82 | CHEK1 (0.69) | NTRK1SYKCHEK1NTRK3NTRK2 | |
| SCHEMBL7553391 | 0.82 | CHEK1 (0.69) | NTRK1SYKCHEK1NTRK3NTRK2 | |
| SCHEMBL7558047 | 0.82 | CHEK1 (0.66) | NTRK1SYKCHEK1NTRK3NTRK2 | |
| SCHEMBL7558053 | 0.82 | CHEK1 (0.66) | NTRK1SYKCHEK1NTRK3NTRK2 | |
| SCHEMBL7553859 | 0.82 | CHEK1 (0.57) | NTRK1SYKCHEK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715628-B1 | SUBSTITUTED AZAINDOLYLIDENE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA ITALIA SPA (IT) | 2002-10-02 | — | — | EP | claimed |