SCHEMBL7549762

SCHEMBL7549762

C[Si](C)(C)C1c2ccccc2C2C=CCCC21

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HSPA1A P0DMV8 1/20 0.33
PTPN7 P35236 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.32
ALOX15 P16050 1/20 0.32
MAPK1 P28482 1/20 0.32
KMT2A Q03164 1/20 0.32
MCL1 Q07820 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HSD17B10 Q99714 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7625415 0.90 HSPA1A (0.33) HSPA1APTPN7TDP1KDM4EMEN1
SCHEMBL7546547 0.83 MAPT (0.33) KDM4EMEN1ALDH1A1MAPTHPGD
SCHEMBL8673572 0.81
SCHEMBL8854288 0.80
Hydrochloric Acid SCHEMBL8673912 0.79
SCHEMBL7542757 0.78 KDM4E (0.30) KDM4EMEN1ALDH1A1MAPTHPGD
SCHEMBL7641216 0.77 HSPA1A (0.33) HSPA1APTPN7TDP1KDM4EMEN1
SCHEMBL6932056 0.77 HSPA1A (0.33) HSPA1APTPN7TDP1KDM4EMEN1
Chloromethane SCHEMBL8162538 0.77 HSPA1A (0.31) HSPA1APTPN7TDP1
Hydrochloric Acid SCHEMBL8161492 0.76 MAPT (0.33) HSPA1APTPN7TDP1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0900228-B1 A METHOD FOR PRODUCING OCTAHYDROFLUORENYL METAL COMPLEXES DOW CHEMICAL CO (US) 2002-06-12 EP disclosed
EP-0900228-A1 A METHOD FOR PRODUCING OCTAHYDROFLUORENYL METAL COMPLEXES THE DOW CHEMICAL COMPANY (US) 1999-03-10 EP disclosed
WO-1997041134-A1 A METHOD FOR PRODUCING OCTAHYDROFLUORENYL METAL COMPLEXES THE DOW CHEMICAL COMPANY (US) 1997-11-06 WO disclosed
US-5670680-A Method for producing octahydrofluorenyl metal complexes THE DOW CHEMICAL COMPANY (US) 1997-09-23 US disclosed