HSPA1A

Heat shock 70 kDa protein 1A · P0DMV8 · HSPA1A on Sugi Atlas →

4,677 patent compounds predicted against HSPA1A, 3,343 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2116528 SCHEMBL2116528 1.00 12/20
SCHEMBL2808722 SCHEMBL2808722 1.00 12/20
SCHEMBL2116204 SCHEMBL2116204 0.85 12/20
SCHEMBL3610631 SCHEMBL3610631 0.73 12/20
SCHEMBL1066515 SCHEMBL1066515 1.00 10/20
SCHEMBL2059580 SCHEMBL2059580 0.69 10/20
SCHEMBL2117317 SCHEMBL2117317 1.00 9/20
SCHEMBL2117400 SCHEMBL2117400 1.00 9/20
SCHEMBL2116061 SCHEMBL2116061 1.00 8/20
SCHEMBL2804418 SCHEMBL2804418 0.81 8/20
SCHEMBL832933 SCHEMBL832933 0.54 6/20
SCHEMBL4278363 SCHEMBL4278363 0.53 5/20
SCHEMBL2777685 SCHEMBL2777685 1.00 4/20
SCHEMBL2778459 SCHEMBL2778459 1.00 4/20
SCHEMBL2846323 SCHEMBL2846323 1.00 4/20
SCHEMBL2846330 SCHEMBL2846330 1.00 4/20
SCHEMBL5080754 SCHEMBL5080754 1.00 4/20
SCHEMBL2789188 SCHEMBL2789188 0.82 4/20
SCHEMBL2779461 SCHEMBL2779461 0.67 4/20
SCHEMBL2779115 SCHEMBL2779115 0.66 4/20

Clinical trials — most relevant to HSPA1A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Spironolactone on Acute Kidney Injury in Critically Ill Patients PHASE3UNKNOWN
17AAG to Treat Kidney Tumors in Von Hippel-Lindau Disease PHASE2COMPLETED
OGX-427 in Castration Resistant Prostate Cancer Patients PHASE2COMPLETED
Gemcitabine, Docetaxel, and Hydroxychloroquine in Treating Participants With Recurrent or Refractory Osteosarcoma PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Phase 1/ Phase 2 Study to Assess Safety and Efficacy of Orally Administered JBI-802 in Subjects With Myeloproliferative Neoplasms (MPN) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) With Thrombocytosis PHASE1/PHASE2RECRUITING
A Phase 2 Study to Investigate the Clinical Activity of IPI-504 in Patients With Hormone-resistant Prostate Cancer PHASE2COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors PHASE1COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors PHASE1COMPLETED
HS-201, an HSP90 Inhibitor-linked Verteporfin for Detection of Solid Malignancies PHASE1WITHDRAWN
17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Solid Tumors That Cannot Be Removed By Surgery PHASE1COMPLETED
Once or Twice Daily Administration of BIIB021 to Subjects With Advanced Solid Tumors PHASE1COMPLETED
Safety and Pharmacology Study of SNX-5422 in Subjects With Resistant Lung Adenocarcinoma PHASE1COMPLETED
SNX-5422 to Treat Solid Tumor Cancers and Lymphomas PHASE1COMPLETED
Safety Study of IPI-504 in Patients With Relapsed and Relapsed Refractory Multiple Myeloma PHASE1COMPLETED
Effect of Propofol and Sevoflurane Anesthesia on HSP70 Expression in Tumor Cells EARLY_PHASE1ACTIVE_NOT_RECRUITING
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC nanCOMPLETED
Perfusion-Induced Hyperthermia for Metastatic Carcinoma nanCOMPLETED
Exercise on Expression of Heat Shock Protein 70 in Arterial Risk nanCOMPLETED
Acute Passive Heating in Healthy Older Adults nanCOMPLETED
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) nanRECRUITING
The Role of HSP90 in Peripheral Vascular Lesions of Diabetic Atherosclerosis nanCOMPLETED
Chronic Heat Therapy for Improving Vascular Health nanCOMPLETED
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases. nanNOT_YET_RECRUITING
Trial of Nonsurgical Treatment of Intermittent Claudication Due to Femoro-popliteal Disease nanCOMPLETED
BASE HSP110 : A New Therapeutic Target and a New Marker for Prognosis of Type MSI Colorectal Cancer nanUNKNOWN
Chronic Passive Heating in Healthy Older Adults nanCOMPLETED
Cardioprotective Benefit of Passive Heat Therapy in Higher-Level Spinal Cord Injury: Safety and Proof of Concept nanUNKNOWN
Reduced Ventilator-Free Days and Bacterial Colonization of Sub-Glottic Secretions nanWITHDRAWN
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia nanRECRUITING
Role of Sorcin and Annexin A3 in Breast Cancer Patients nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a HSPA1A binder may also engage these)

ProteinNameSimilarity
Q6S4N2 1.000 Q6S4N2 →
Q5R7D3 1.000 Q5R7D3 →
HSPA1B Heat shock 70 kDa protein 1B (Heat shock 70 k 1.000 landscape →
Q61696 1.000 Q61696 →
P0DMW1 1.000 P0DMW1 →
P0DMW0 1.000 P0DMW0 →
P34933 1.000 P34933 →
Q27965 1.000 Q27965 →
HSPA2 Heat shock-related 70 kDa protein 2 1.000 landscape →
Q4U0F3 1.000 Q4U0F3 →
Q27975 1.000 Q27975 →
P17879 1.000 P17879 →
Q9TUG3 1.000 Q9TUG3 →
P08418 1.000 P08418 →
Q01233 1.000 Q01233 →
P63017 1.000 P63017 →
P25840 1.000 P25840 →
P19378 1.000 P19378 →
P87047 1.000 P87047 →
Q9VG58 1.000 Q9VG58 →
P34930 1.000 P34930 →
Q7YQC6 1.000 Q7YQC6 →
P17156 1.000 P17156 →
Q9BIS2 1.000 Q9BIS2 →
P82910 1.000 P82910 →
Q9I8F9 1.000 Q9I8F9 →
HSPA8 Heat shock cognate 71 kDa protein 1.000 landscape →
P14659 1.000 P14659 →
A2Q0Z1 1.000 A2Q0Z1 →
Q90473 1.000 Q90473 →