Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | PPARD | Q03181 | 8/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549997 | 1.00 | ACHE (0.55) | ACHEDRD2DRD3PPARDALB | |
| Hydrochloric Acid SCHEMBL7543057 | 0.99 | ACHE (0.54) | ACHEDRD2DRD3PPARDALB | |
| Hydrochloric Acid SCHEMBL7543050 | 0.99 | ACHE (0.54) | ACHEDRD2DRD3PPARDALB | |
| SCHEMBL5722323 | 0.85 | HSD17B10 (0.62) | ACHEDRD2DRD3PPARDALOX15 | |
| SCHEMBL5722321 | 0.85 | HSD17B10 (0.62) | ACHEDRD2DRD3PPARDALOX15 | |
| SCHEMBL9305716 | 0.84 | BRD4 (0.56) | ACHEDRD2DRD3PPARD | |
| Hydrochloric Acid SCHEMBL7545794 | 0.84 | HSD17B10 (0.61) | ACHEDRD2DRD3PPARDALOX15 | |
| Hydrochloric Acid SCHEMBL7545790 | 0.84 | HSD17B10 (0.61) | ACHEDRD2DRD3PPARDALOX15 | |
| SCHEMBL9303733 | 0.83 | BRD4 (0.55) | ACHEDRD2DRD3PPARD | |
| Hydrochloric Acid SCHEMBL9305103 | 0.83 | BRD4 (0.55) | ACHEDRD2DRD3PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894787-B1 | 3,4-DISUBSTITUTED PHENYLETHANOLAMINOTETRALINCARBOXYLATE DERIVATIVES | KISSEI PHARMACEUTICAL (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-6136852-A | 3,4-disubstituted phenylethanolaminotetralincarboxylic acid derivatives | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0894787-A1 | 3,4-DISUBSTITUTED PHENYLETHANOLAMINOTETRALINCARBOXYLATE DERIVATIVES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1999-02-03 | — | — | EP | disclosed |