Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | ERN1 | O75460 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7544435 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2HTTNPC1RAB9AEGFR | |
| SCHEMBL12697047 | 0.83 | SMN1; SMN2 (0.64) | SMN1; SMN2HTTNPC1RAB9ANR1H4 | |
| SCHEMBL27916802 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2HTTERN1PPARGPPARA | |
| SCHEMBL17194791 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2HTTNPC1RAB9AEPHX2 | |
| SCHEMBL18560604 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2HTTNPC1RAB9AEGFR | |
| SCHEMBL6848908 | 0.75 | SMN1; SMN2 (0.66) | SMN1; SMN2L3MBTL1KMT2ALMNAHPGD | |
| SCHEMBL24162968 | 0.75 | HPGD (0.70) | SMN1; SMN2NPC1RAB9AEPHX2NR1H4 | |
| SCHEMBL1926263 | 0.74 | NPC1 (1.00) | SMN1; SMN2HTTNPC1RAB9AEPHX2 | |
| SCHEMBL13812735 | 0.74 | HPGD (0.65) | SMN1; SMN2HTTRAB9AERN1L3MBTL1 | |
| SCHEMBL5681720 | 0.73 | ERCC1 (0.69) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002044128-A2 | SALICYLATE ANALOGS AS INTERLEUKIN-4 ANTAGONISTS | SUNESIS PHARMACEUTICALS, INC. (US) | 2002-06-06 | — | — | WO | disclosed |